BindingDB PrimarySearch

BDBM50115579 (Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid::2-Hydroxy-4-oxo-4-phenyl-but-2-enoic acid::2-Hydroxy-4-oxo-4-phenyl-but-2-enoic acid (0.25H2O)::CHEMBL16326::CHEMBL19332::CHEMBL467389::Sacchettini_CTRL

SMILES: OC(=O)C(=O)CC(=O)c1ccccc1

InChI Key: InChIKey=JGKFWCXVYCDKDU-UHFFFAOYSA-N

Data: 5 KI 23 IC50 1 EC50

PDB links: 6 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50115579
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
PA/PB1 (Hepatitis C virus)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Binding affinity to PA N-terminal domain (Competitive)				ACS Chem Biol 7: 526-34 (2012) Article DOI: 10.1021/cb200439z BindingDB Entry DOI: 10.7270/Q2JQ121G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.35E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Inhibition of human CA1 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique				Bioorg Med Chem Lett 22: 5801-6 (2012) Article DOI: 10.1016/j.bmcl.2012.07.094 BindingDB Entry DOI: 10.7270/Q2319X0G
Universit£ di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Inhibition of human CA2 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique				Bioorg Med Chem Lett 22: 5801-6 (2012) Article DOI: 10.1016/j.bmcl.2012.07.094 BindingDB Entry DOI: 10.7270/Q2319X0G
Universit£ di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	6.79E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Inhibition of human CA9 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique				Bioorg Med Chem Lett 22: 5801-6 (2012) Article DOI: 10.1016/j.bmcl.2012.07.094 BindingDB Entry DOI: 10.7270/Q2319X0G
Universit£ di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.75E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Inhibition of human CA12 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique				Bioorg Med Chem Lett 22: 5801-6 (2012) Article DOI: 10.1016/j.bmcl.2012.07.094 BindingDB Entry DOI: 10.7270/Q2319X0G
Universit£ di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B is determined				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
Italy. Vinc Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université des Sciences et Technologies de Lille Curated by ChEMBL					Assay Description Concentration required to inhibit strand transfer of HIV-1 integrase using Mn2+ as a divalent cation source.				J Med Chem 47: 5583-6 (2004) Article DOI: 10.1021/jm0408464 BindingDB Entry DOI: 10.7270/Q2JS9PX9
					More data for this Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	7.5	n/a
University of Rome La Sapienza Curated by ChEMBL					Assay Description Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)				J Med Chem 48: 6304-14 (2005) Article DOI: 10.1021/jm0504454 BindingDB Entry DOI: 10.7270/Q2T43SNM
University of Rome La Sapienza Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
Università di Messina Curated by ChEMBL					Assay Description Strand transfer inhibitory activity against HIV-1 integrase				J Med Chem 48: 7084-8 (2005) Article DOI: 10.1021/jm050549e BindingDB Entry DOI: 10.7270/Q27W6BR1
Università di Messina Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Università di Sassari Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase 3' processing activity				J Med Chem 49: 4248-60 (2006) Article DOI: 10.1021/jm060193m BindingDB Entry DOI: 10.7270/Q2T15384
Università di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Università di Sassari Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase strand transfer activity				J Med Chem 49: 4248-60 (2006) Article DOI: 10.1021/jm060193m BindingDB Entry DOI: 10.7270/Q2T15384
Università di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Università di Sassari Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase 3' processing activity in presence of exogenous cobalt ion				J Med Chem 49: 4248-60 (2006) Article DOI: 10.1021/jm060193m BindingDB Entry DOI: 10.7270/Q2T15384
Università di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Università di Sassari Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase strand transfer activity in presence of exogenous cobalt ion				J Med Chem 49: 4248-60 (2006) Article DOI: 10.1021/jm060193m BindingDB Entry DOI: 10.7270/Q2T15384
Università di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
PA/PB1 (Hepatitis C virus)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Discovery Welwyn Curated by ChEMBL					Assay Description Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP				J Med Chem 46: 1153-64 (2003) Article DOI: 10.1021/jm020334u BindingDB Entry DOI: 10.7270/Q22J6B6V
Roche Discovery Welwyn Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Flap endonuclease 1 (Homo sapiens (Human))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.49E+4	n/a	n/a	n/a	n/a	n/a	n/a
Athersys, Inc. Curated by ChEMBL					Assay Description Concentration required for 50% inhibition of Flap endonuclease-1				Bioorg Med Chem Lett 14: 4915-8 (2004) Article DOI: 10.1016/j.bmcl.2004.07.028 BindingDB Entry DOI: 10.7270/Q2ZC82BF
Athersys, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
DNA excision repair protein ERCC-5 (Homo sapiens (Human))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
Athersys, Inc. Curated by ChEMBL					Assay Description Concentration required for 50% inhibition of Xeroderma pigmentosum G				Bioorg Med Chem Lett 14: 4915-8 (2004) Article DOI: 10.1016/j.bmcl.2004.07.028 BindingDB Entry DOI: 10.7270/Q2ZC82BF
Athersys, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max-Planck-Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of PTP1B				Bioorg Med Chem 19: 2145-55 (2011) Article DOI: 10.1016/j.bmc.2011.02.047 BindingDB Entry DOI: 10.7270/Q2BR8SHK
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute/NIH Curated by ChEMBL					Assay Description Inhibitory effect on 3'-processing(3'-P) of proviral DNA in an extracellular HIV-1 integrase assay				J Med Chem 45: 3184-94 (2002) BindingDB Entry DOI: 10.7270/Q26D5TPD
National Cancer Institute/NIH Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute/NIH Curated by ChEMBL					Assay Description Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2				J Med Chem 45: 3184-94 (2002) BindingDB Entry DOI: 10.7270/Q26D5TPD
National Cancer Institute/NIH Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute/NIH Curated by ChEMBL					Assay Description Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1				J Med Chem 45: 3184-94 (2002) BindingDB Entry DOI: 10.7270/Q26D5TPD
National Cancer Institute/NIH Curated by ChEMBL					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus (HCV))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Wollongong Curated by ChEMBL					Assay Description Inhibitory concentration against hepatitis C virus polymerase				J Med Chem 48: 1-20 (2005) Article DOI: 10.1021/jm0400101 BindingDB Entry DOI: 10.7270/Q2XP75Q1
University of Wollongong Curated by ChEMBL					More data for this Ligand-Target Pair
PA/PB1 (Hepatitis C virus)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	2.07E+3	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Plaque growth inhibition				ACS Chem Biol 7: 526-34 (2012) Article DOI: 10.1021/cb200439z BindingDB Entry DOI: 10.7270/Q2JQ121G
					More data for this Ligand-Target Pair				3D Structure (crystal)
PA/PB1 (Hepatitis C virus)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	2.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of cap 1 ALMV primed Influenza transcriptase				Antimicrob Agents Chemother 38: 2827-37 (1995) BindingDB Entry DOI: 10.7270/Q25H7HBP
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
MRL Rome Curated by ChEMBL					Assay Description inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus				Bioorg Med Chem Lett 14: 5085-8 (2004) Article DOI: 10.1016/j.bmcl.2004.07.075 BindingDB Entry DOI: 10.7270/Q27P8XV3
MRL Rome Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
NCI-Frederick Curated by ChEMBL					Assay Description Inhibition of Integrase catalyzed strand transfer (ST) as measured in an in vitro assay				Bioorg Med Chem Lett 14: 1205-7 (2004) Article DOI: 10.1016/j.bmcl.2003.12.064 BindingDB Entry DOI: 10.7270/Q23X8628
NCI-Frederick Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory activity of the compound against HIV-1 reverse transcriptase was determined				J Med Chem 47: 14-7 (2003) Article DOI: 10.1021/jm0342109 BindingDB Entry DOI: 10.7270/Q2736QB8
Italy. Vinc Curated by ChEMBL					More data for this Ligand-Target Pair
Polymerase acidic protein (Influenza A virus (strain A/X-31 H3N2))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Polo Universitario SS. Annunziata Curated by ChEMBL					Assay Description Inhibition of recombinant Influenza A virus (A/X-31(H3N2)) N-terminal 6xHis-tagged PA-Nter (1 to 217 residues) expressed in Escherichia coli BL21-Cod...				Bioorg Med Chem 26: 4544-4550 (2018) Article DOI: 10.1016/j.bmc.2018.07.046 BindingDB Entry DOI: 10.7270/Q2TM7DS6
Polo Universitario SS. Annunziata Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GlcB (Homo sapiens (Human))	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB D3R	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
D3R					Assay Description DNTB-Coupled_Enzyme_Assay				D3R 223: (2015) BindingDB Entry DOI: 10.7270/Q2NC602G
D3R					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50115579 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid \| 2-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1 Show InChI	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B				J Med Chem 47: 14-7 (2003) Article DOI: 10.1021/jm0342109 BindingDB Entry DOI: 10.7270/Q2736QB8
Italy. Vinc Curated by ChEMBL					More data for this Ligand-Target Pair