BDBM50115914 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-chloro-benzyl ester::CHEMBL291580

SMILES: Clc1ccccc1COC(=O)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1

InChI Key: InChIKey=XRJFAINHZHMKOK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50115914   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50115914 (4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...) Show SMILES Clc1ccccc1COC(=O)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C24H24ClN5O2/c25-23-4-2-1-3-21(23)17-32-24(31)29-11-9-28(10-12-29)16-22-14-27-18-30(22)15-20-7-5-19(13-26)6-8-20/h1-8,14,18H,9-12,15-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitor of Farnesyl protein transferase(FTPase) required to reduce radiolabel [1-3H] incorporation by 50%				Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50115914 (4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...) Show SMILES Clc1ccccc1COC(=O)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C24H24ClN5O2/c25-23-4-2-1-3-21(23)17-32-24(31)29-11-9-28(10-12-29)16-22-14-27-18-30(22)15-20-7-5-19(13-26)6-8-20/h1-8,14,18H,9-12,15-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of geranyl-geranylation of C-terminal CAAX sequence of Rap 1a in PSN-1 cells				Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50115914 (4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...) Show SMILES Clc1ccccc1COC(=O)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C24H24ClN5O2/c25-23-4-2-1-3-21(23)17-32-24(31)29-11-9-28(10-12-29)16-22-14-27-18-30(22)15-20-7-5-19(13-26)6-8-20/h1-8,14,18H,9-12,15-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description The concentration required to displace 50% of a highly potent radiolabeled FPTase inhibitor				Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS
					More data for this Ligand-Target Pair