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SMILES: Nc1nc(N)c(F)c(-c2nc(c([nH]2)-c2cccc(c2)C(F)(F)F)-c2ccncc2)c1F

InChI Key: InChIKey=GZPQHXFTOBWRKR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50116034   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Mus musculus (mouse))	BDBM50116034 (3,5-Difluoro-4-[5-pyridin-4-yl-4-(3-trifluoromethy...) Show SMILES Nc1nc(N)c(F)c(-c2nc(c([nH]2)-c2cccc(c2)C(F)(F)F)-c2ccncc2)c1F Show InChI InChI=1S/C20H13F5N6/c21-13-12(14(22)18(27)31-17(13)26)19-29-15(9-4-6-28-7-5-9)16(30-19)10-2-1-3-11(8-10)20(23,24)25/h1-8H,(H,29,30)(H4,26,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP				Bioorg Med Chem Lett 12: 2109-12 (2002) BindingDB Entry DOI: 10.7270/Q2610ZNX
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50116034 (3,5-Difluoro-4-[5-pyridin-4-yl-4-(3-trifluoromethy...) Show SMILES Nc1nc(N)c(F)c(-c2nc(c([nH]2)-c2cccc(c2)C(F)(F)F)-c2ccncc2)c1F Show InChI InChI=1S/C20H13F5N6/c21-13-12(14(22)18(27)31-17(13)26)19-29-15(9-4-6-28-7-5-9)16(30-19)10-2-1-3-11(8-10)20(23,24)25/h1-8H,(H,29,30)(H4,26,27,31)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description In vivo inhibition of ram seminal vesicle Prostaglandin G/H synthase 1 activity by determining PGE-2 by RIA				Bioorg Med Chem Lett 12: 2109-12 (2002) BindingDB Entry DOI: 10.7270/Q2610ZNX
					More data for this Ligand-Target Pair