Found 4 hits for monomerid = 50116831 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
ATP-sensitive inward rectifier potassium channel 1
(Homo sapiens (Human)) | BDBM50116831
(CHEMBL3612927)Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(CC(O)c2cc(c(cn2)C#N)C(F)(F)F)CC1 |r| Show InChI InChI=1S/C24H25F3N4O4/c1-14-16(2-3-17-18(14)13-35-23(17)34)21(32)11-30-4-6-31(7-5-30)12-22(33)20-8-19(24(25,26)27)15(9-28)10-29-20/h2-3,8,10,21-22,32-33H,4-7,11-13H2,1H3/t21-,22?/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of ROMK (unknown origin) expressed in HEK293 cells by thallium flux assay |
ACS Med Chem Lett 6: 747-52 (2015)
BindingDB Entry DOI: 10.7270/Q27H1MCQ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50116831
(CHEMBL3612927)Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(CC(O)c2cc(c(cn2)C#N)C(F)(F)F)CC1 |r| Show InChI InChI=1S/C24H25F3N4O4/c1-14-16(2-3-17-18(14)13-35-23(17)34)21(32)11-30-4-6-31(7-5-30)12-22(33)20-8-19(24(25,26)27)15(9-28)10-29-20/h2-3,8,10,21-22,32-33H,4-7,11-13H2,1H3/t21-,22?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells |
ACS Med Chem Lett 6: 747-52 (2015)
BindingDB Entry DOI: 10.7270/Q27H1MCQ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50116831
(CHEMBL3612927)Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(CC(O)c2cc(c(cn2)C#N)C(F)(F)F)CC1 |r| Show InChI InChI=1S/C24H25F3N4O4/c1-14-16(2-3-17-18(14)13-35-23(17)34)21(32)11-30-4-6-31(7-5-30)12-22(33)20-8-19(24(25,26)27)15(9-28)10-29-20/h2-3,8,10,21-22,32-33H,4-7,11-13H2,1H3/t21-,22?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells |
ACS Med Chem Lett 6: 747-52 (2015)
BindingDB Entry DOI: 10.7270/Q27H1MCQ |
More data for this
Ligand-Target Pair | |
ATP-sensitive inward rectifier potassium channel 1
(Homo sapiens (Human)) | BDBM50116831
(CHEMBL3612927)Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(CC(O)c2cc(c(cn2)C#N)C(F)(F)F)CC1 |r| Show InChI InChI=1S/C24H25F3N4O4/c1-14-16(2-3-17-18(14)13-35-23(17)34)21(32)11-30-4-6-31(7-5-30)12-22(33)20-8-19(24(25,26)27)15(9-28)10-29-20/h2-3,8,10,21-22,32-33H,4-7,11-13H2,1H3/t21-,22?/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of ROMK (unknown origin) expressed in HEK293 cells by thallium flux assay |
ACS Med Chem Lett 6: 747-52 (2015)
BindingDB Entry DOI: 10.7270/Q27H1MCQ |
More data for this
Ligand-Target Pair | |
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