BDBM50117380 4-{6-Methoxy-7-[3-(3-methyl-butane-1-sulfonyl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide::CHEMBL339403

SMILES: COc1cc2c(ncnc2cc1OCCCS(=O)(=O)CCC(C)C)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1

InChI Key: InChIKey=WTFQTDJXZDGOHR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50117380   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50117380 (4-{6-Methoxy-7-[3-(3-methyl-butane-1-sulfonyl)-pro...) Show SMILES COc1cc2c(ncnc2cc1OCCCS(=O)(=O)CCC(C)C)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 Show InChI InChI=1S/C31H43N5O6S/c1-22(2)11-18-43(38,39)17-6-16-41-29-20-27-26(19-28(29)40-5)30(33-21-32-27)35-12-14-36(15-13-35)31(37)34-24-7-9-25(10-8-24)42-23(3)4/h7-10,19-23H,6,11-18H2,1-5H3,(H,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma				J Med Chem 45: 3772-93 (2002) BindingDB Entry DOI: 10.7270/Q2WW7JD9
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50117380 (4-{6-Methoxy-7-[3-(3-methyl-butane-1-sulfonyl)-pro...) Show SMILES COc1cc2c(ncnc2cc1OCCCS(=O)(=O)CCC(C)C)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 Show InChI InChI=1S/C31H43N5O6S/c1-22(2)11-18-43(38,39)17-6-16-41-29-20-27-26(19-28(29)40-5)30(33-21-32-27)35-12-14-36(15-13-35)31(37)34-24-7-9-25(10-8-24)42-23(3)4/h7-10,19-23H,6,11-18H2,1-5H3,(H,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma				J Med Chem 45: 3772-93 (2002) BindingDB Entry DOI: 10.7270/Q2WW7JD9
					More data for this Ligand-Target Pair