BDBM50117723 8-(2-Isobutoxy-phenyl)-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione::CHEMBL316372

SMILES: CC(C)COc1ccccc1-c1nc2n(CC(C)C)c(=O)n(C)c(=O)c2[nH]1

InChI Key: InChIKey=AITUJCIJLSDPOL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50117723   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 6 (Bos taurus-Bos taurus (Bovine))	BDBM50117723 (8-(2-Isobutoxy-phenyl)-3-isobutyl-1-methyl-3,7-dih...) Show SMILES CC(C)COc1ccccc1-c1nc2n(CC(C)C)c(=O)n(C)c(=O)c2[nH]1 Show InChI InChI=1S/C20H26N4O3/c1-12(2)10-24-18-16(19(25)23(5)20(24)26)21-17(22-18)14-8-6-7-9-15(14)27-11-13(3)4/h6-9,12-13H,10-11H2,1-5H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Horsham Research Centre Curated by ChEMBL					Assay Description Inhibitory concentration against bovine retina phosphodiesterase 6 activity				Bioorg Med Chem Lett 12: 2587-90 (2002) BindingDB Entry DOI: 10.7270/Q2KW5FC2
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50117723 (8-(2-Isobutoxy-phenyl)-3-isobutyl-1-methyl-3,7-dih...) Show SMILES CC(C)COc1ccccc1-c1nc2n(CC(C)C)c(=O)n(C)c(=O)c2[nH]1 Show InChI InChI=1S/C20H26N4O3/c1-12(2)10-24-18-16(19(25)23(5)20(24)26)21-17(22-18)14-8-6-7-9-15(14)27-11-13(3)4/h6-9,12-13H,10-11H2,1-5H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Horsham Research Centre Curated by ChEMBL					Assay Description Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)				Bioorg Med Chem Lett 12: 2587-90 (2002) BindingDB Entry DOI: 10.7270/Q2KW5FC2
					More data for this Ligand-Target Pair