BDBM50118260 9-(4-Hydroxy-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza-fluoren-9-ol::CHEMBL130668
SMILES: Oc1ccc(cc1)C1(O)N2CCCN=C2c2ccccc12
InChI Key: InChIKey=NFNRNOMETYDQMI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50118260 (9-(4-Hydroxy-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Displacement of [125I]- RTI-55 from Serotonin transporter expressed in HEK cells | J Med Chem 45: 4097-109 (2002) BindingDB Entry DOI: 10.7270/Q2MC90R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50118260 (9-(4-Hydroxy-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 87.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Displacement of [125I]- RTI-55 from Dopamine transporter expressed in HEK cells | J Med Chem 45: 4097-109 (2002) BindingDB Entry DOI: 10.7270/Q2MC90R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50118260 (9-(4-Hydroxy-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Displacement of [125I]RTI-55 from human Norepinephrine transporter expressed in HEK cells | J Med Chem 45: 4097-109 (2002) BindingDB Entry DOI: 10.7270/Q2MC90R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50118260 (9-(4-Hydroxy-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Inhibition of NE uptake in HEK cells expressing human noradrenaline transporter (hNET) | J Med Chem 45: 4097-109 (2002) BindingDB Entry DOI: 10.7270/Q2MC90R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50118260 (9-(4-Hydroxy-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Inhibition of 5-HT uptake in HEK cells expressing human serotonin transporter (hSERT) | J Med Chem 45: 4097-109 (2002) BindingDB Entry DOI: 10.7270/Q2MC90R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50118260 (9-(4-Hydroxy-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Ability to displace [3H]WIN-35428 from Dopamine Transporter of rat striatal membrane | J Med Chem 45: 4097-109 (2002) BindingDB Entry DOI: 10.7270/Q2MC90R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50118260 (9-(4-Hydroxy-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program/NIH Curated by ChEMBL | Assay Description Ability to displace [3H]-WIN-35,428 from dopamine transporter in rat caudate putamen tissue | J Med Chem 45: 4119-27 (2002) BindingDB Entry DOI: 10.7270/Q21Z43R6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50118260 (9-(4-Hydroxy-phenyl)-1,2,3,9-tetrahydro-4,9a-diaza...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Inhibition of dopamine uptake in HEK cells expressing human dopamine transporter (hDAT) | J Med Chem 45: 4097-109 (2002) BindingDB Entry DOI: 10.7270/Q2MC90R8 | |||||||||||
More data for this Ligand-Target Pair |