BDBM50118294 7-(4-Chloro-phenyl)-7,8,9,10-tetrahydro-7a,11-diaza-benzo[c]fluoren-7-ol::CHEMBL334577
SMILES: OC1(N2CCCN=C2c2c1ccc1ccccc21)c1ccc(Cl)cc1
InChI Key: InChIKey=ADCPRYKGPAHETD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50118294 (7-(4-Chloro-phenyl)-7,8,9,10-tetrahydro-7a,11-diaz...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.01 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Inhibition of [125I]- RTI -55 binding at the Dopamine transporter sites on HEK-hDAT cells | J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50118294 (7-(4-Chloro-phenyl)-7,8,9,10-tetrahydro-7a,11-diaz...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Inhibition of [125I]- RTI -55 binding at the Norepinephrin transpoter sites on HEK-hNET cells | J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50118294 (7-(4-Chloro-phenyl)-7,8,9,10-tetrahydro-7a,11-diaz...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Inhibition of [125I]- RTI -55 binding at the Serotonin transporter sites on HEK-hSERT cells | J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50118294 (7-(4-Chloro-phenyl)-7,8,9,10-tetrahydro-7a,11-diaz...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 37.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Ability to displace [3H]- WIN 35,428 from dopamine transporter on rat striatal membrane. | J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50118294 (7-(4-Chloro-phenyl)-7,8,9,10-tetrahydro-7a,11-diaz...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Drew University Curated by ChEMBL | Assay Description Ability to displace [3H]- WIN 35,428 from dopamine transporter on guinea pig striatal membrane. | J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50118294 (7-(4-Chloro-phenyl)-7,8,9,10-tetrahydro-7a,11-diaz...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program/NIH Curated by ChEMBL | Assay Description Ability to displace [3H]-WIN-35,428 from dopamine transporter in rat caudate putamen tissue | J Med Chem 45: 4119-27 (2002) BindingDB Entry DOI: 10.7270/Q21Z43R6 | |||||||||||
More data for this Ligand-Target Pair |