BDBM50118696 5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-2-fluoro-benzonitrile::5-(4,4-dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazin-6-yl)-2-fluorobenzonitrile::CHEMBL136721
SMILES: CC1(C)OC(=O)Nc2ccc(cc12)-c1ccc(F)c(c1)C#N
InChI Key: InChIKey=QYXWQJJMCRIUKE-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Progesterone receptor (Homo sapiens (Human)) | BDBM50118696 (5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Women's Health Research Institute Curated by ChEMBL | Assay Description Inhibition of human progesterone receptor | J Med Chem 48: 5092-5 (2005) Article DOI: 10.1021/jm050358b BindingDB Entry DOI: 10.7270/Q2FF3RXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50118696 (5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Women's Health Research Institute Curated by ChEMBL | Assay Description Antagonist activity against progesterone receptor (PR) in an assay using PRE-luciferase plasmid co-transfected CV-1 cells | J Med Chem 45: 4379-82 (2002) BindingDB Entry DOI: 10.7270/Q22F7P5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50118696 (5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 15.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Women's Health Research Institute Curated by ChEMBL | Assay Description Antagonist activity against progesterone receptor (PR) in an alkaline phosphatase assay in the T47D human breast carcinoma cell line | J Med Chem 45: 4379-82 (2002) BindingDB Entry DOI: 10.7270/Q22F7P5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50118696 (5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 15.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Antagonist activity at progesterone receptor expressed in T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity | Bioorg Med Chem Lett 17: 189-92 (2006) Article DOI: 10.1016/j.bmcl.2006.09.060 BindingDB Entry DOI: 10.7270/Q2D21X85 | |||||||||||
More data for this Ligand-Target Pair |