BindingDB PrimarySearch

BDBM50118750 2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid::CHEMBL140120

SMILES: OC(=O)C(=O)Nc1sc2CN(CCc3ccccc3)CCc2c1C(O)=O

InChI Key: InChIKey=ZIMJSFGMHLCHIV-UHFFFAOYSA-N

Data: 8 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50118750
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50118750 (2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-th...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	270	n/a	n/a	n/a	n/a	n/a	n/a	5.5	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant PTP1B (1 to 321 residues) catalytic domain expressed in Escherichia coli BL21 (DE3) cells using p-nitrophenyl phospha...				Bioorg Med Chem 24: 3343-52 (2016) BindingDB Entry DOI: 10.7270/Q20Z756P
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50118750 (2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-th...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	270	n/a	n/a	n/a	n/a	n/a	n/a	5.5	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory effect against recombinant human protein-tyrosine phosphatase 1B (PTP1B), using p-nitrophenyl phosphate substrate at pH 5.5.				J Med Chem 45: 4443-59 (2002) BindingDB Entry DOI: 10.7270/Q2QJ7GM5
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50118750 (2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-th...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of human recombinant Protein-tyrosine phosphatase 1B.				J Med Chem 45: 4443-59 (2002) BindingDB Entry DOI: 10.7270/Q2QJ7GM5
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50118750 (2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-th...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of human recombinant Protein-tyrosine phosphatase 1B.				J Med Chem 45: 4443-59 (2002) BindingDB Entry DOI: 10.7270/Q2QJ7GM5
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50118750 (2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-th...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.0	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant TCPTP (unknown origin) at pH 7				Bioorg Med Chem 24: 3343-52 (2016) BindingDB Entry DOI: 10.7270/Q20Z756P
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Leukocyte common antigen (Homo sapiens (Human))	BDBM50118750 (2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-th...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.40E+6	n/a	n/a	n/a	n/a	n/a	n/a	7.0	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory effect against human CD45 tyrosine phosphatase using p-nitrophenyl phosphate substrate at a pH 7.0				J Med Chem 45: 4443-59 (2002) BindingDB Entry DOI: 10.7270/Q2QJ7GM5
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase alpha (Homo sapiens (Human))	BDBM50118750 (2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-th...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.10E+6	n/a	n/a	n/a	n/a	n/a	n/a	7.0	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory effect against human Protein-tyrosine phosphatase alpha (PTPalpha) using p-nitrophenyl phosphate substrate at a pH 7.0				J Med Chem 45: 4443-59 (2002) BindingDB Entry DOI: 10.7270/Q2QJ7GM5
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR) (Homo sapiens (Human))	BDBM50118750 (2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-th...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.10E+6	n/a	n/a	n/a	n/a	n/a	n/a	7.0	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory effect against human Protein-tyrosine phosphatase Lar using p-nitrophenyl phosphate substrate at a pH 7.0				J Med Chem 45: 4443-59 (2002) BindingDB Entry DOI: 10.7270/Q2QJ7GM5
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair