null

SMILES: OC1CCc2c(C1)sc(NC(=O)C(O)=O)c2C(O)=O

InChI Key: InChIKey=VUGHDZNNBFETOT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50118771   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50118771 (2-(carboxyformamido)-6-hydroxy-4,5,6,7-tetrahydrob...) Show SMILES OC1CCc2c(C1)sc(NC(=O)C(O)=O)c2C(O)=O Show InChI InChI=1S/C11H11NO6S/c13-4-1-2-5-6(3-4)19-9(7(5)10(15)16)12-8(14)11(17)18/h4,13H,1-3H2,(H,12,14)(H,15,16)(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	5.5	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory effect against recombinant human protein-tyrosine phosphatase 1B (PTP1B), using p-nitrophenyl phosphate substrate at pH 5.5.				J Med Chem 45: 4443-59 (2002) BindingDB Entry DOI: 10.7270/Q2QJ7GM5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50118771 (2-(carboxyformamido)-6-hydroxy-4,5,6,7-tetrahydrob...) Show SMILES OC1CCc2c(C1)sc(NC(=O)C(O)=O)c2C(O)=O Show InChI InChI=1S/C11H11NO6S/c13-4-1-2-5-6(3-4)19-9(7(5)10(15)16)12-8(14)11(17)18/h4,13H,1-3H2,(H,12,14)(H,15,16)(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.99E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Graduate University of Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to PTP1B				Bioorg Med Chem Lett 15: 5521-5 (2005) Article DOI: 10.1016/j.bmcl.2005.08.078 BindingDB Entry DOI: 10.7270/Q2TF0139
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50118771 (2-(carboxyformamido)-6-hydroxy-4,5,6,7-tetrahydrob...) Show SMILES OC1CCc2c(C1)sc(NC(=O)C(O)=O)c2C(O)=O Show InChI InChI=1S/C11H11NO6S/c13-4-1-2-5-6(3-4)19-9(7(5)10(15)16)12-8(14)11(17)18/h4,13H,1-3H2,(H,12,14)(H,15,16)(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsinghua University Curated by ChEMBL					Assay Description Binding affinity to human recombinant PTP1B				Bioorg Med Chem Lett 20: 3329-37 (2010) Article DOI: 10.1016/j.bmcl.2010.04.033 BindingDB Entry DOI: 10.7270/Q27D2WCC
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase alpha (Homo sapiens (Human))	BDBM50118771 (2-(carboxyformamido)-6-hydroxy-4,5,6,7-tetrahydrob...) Show SMILES OC1CCc2c(C1)sc(NC(=O)C(O)=O)c2C(O)=O Show InChI InChI=1S/C11H11NO6S/c13-4-1-2-5-6(3-4)19-9(7(5)10(15)16)12-8(14)11(17)18/h4,13H,1-3H2,(H,12,14)(H,15,16)(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.15E+5	n/a	n/a	n/a	n/a	n/a	n/a	5.5	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory effect against human protein-tyrosine phosphatase alpha (PTPalpha), using p-nitrophenyl phosphate substrate at pH 5.5.				J Med Chem 45: 4443-59 (2002) BindingDB Entry DOI: 10.7270/Q2QJ7GM5
					More data for this Ligand-Target Pair