BDBM50118840 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid 3-chloro-benzylamide::CHEMBL141745

SMILES: COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3cccc(Cl)c3)c2cc1OC

InChI Key: InChIKey=SWBJOEDJKOOLRI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50118840   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50118840 (4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...) Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3cccc(Cl)c3)c2cc1OC Show InChI InChI=1S/C22H24ClN5O2S/c1-29-19-11-17-18(12-20(19)30-2)25-14-26-21(17)27-6-8-28(9-7-27)22(31)24-13-15-4-3-5-16(23)10-15/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,24,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...				J Med Chem 45: 4513-23 (2002) BindingDB Entry DOI: 10.7270/Q2JH3MXF
					More data for this Ligand-Target Pair