BDBM50118857 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid 4-methoxy-benzylamide::CHEMBL141460

SMILES: COc1ccc(CNC(=S)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1

InChI Key: InChIKey=SCGYVNOQVNQTNY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50118857   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50118857 (4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...) Show SMILES COc1ccc(CNC(=S)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C23H27N5O3S/c1-29-17-6-4-16(5-7-17)14-24-23(32)28-10-8-27(9-11-28)22-18-12-20(30-2)21(31-3)13-19(18)25-15-26-22/h4-7,12-13,15H,8-11,14H2,1-3H3,(H,24,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...				J Med Chem 45: 4513-23 (2002) BindingDB Entry DOI: 10.7270/Q2JH3MXF
					More data for this Ligand-Target Pair