BDBM50118858 4-(6,7-Dimethoxy-quinazolin-4-yl)-2-methyl-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide::CHEMBL343133

SMILES: COc1cc2ncnc(N3CCN(C(C)C3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC

InChI Key: InChIKey=OSYWVHQKLCIONH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50118858   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50118858 (4-(6,7-Dimethoxy-quinazolin-4-yl)-2-methyl-piperaz...) Show SMILES COc1cc2ncnc(N3CCN(C(C)C3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C28H29N5O4/c1-19-17-32(27-23-15-25(35-2)26(36-3)16-24(23)29-18-30-27)13-14-33(19)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,15-16,18-19H,13-14,17H2,1-3H3,(H,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...				J Med Chem 45: 4513-23 (2002) BindingDB Entry DOI: 10.7270/Q2JH3MXF
					More data for this Ligand-Target Pair