BDBM50118869 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid 4-tert-butyl-benzylamide::CHEMBL336005

SMILES: COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(cc3)C(C)(C)C)c2cc1OC

InChI Key: InChIKey=XBRIIWVCRRXRPA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50118869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50118869 (4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...) Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(cc3)C(C)(C)C)c2cc1OC Show InChI InChI=1S/C26H33N5O3/c1-26(2,3)19-8-6-18(7-9-19)16-27-25(32)31-12-10-30(11-13-31)24-20-14-22(33-4)23(34-5)15-21(20)28-17-29-24/h6-9,14-15,17H,10-13,16H2,1-5H3,(H,27,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...				J Med Chem 45: 4513-23 (2002) BindingDB Entry DOI: 10.7270/Q2JH3MXF
					More data for this Ligand-Target Pair