Found 2 hits for monomerid = 50121477 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50121477
(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)Show SMILES Cc1cc2c(cc1Cc1ccc(o1)C(=O)NC[C@H]1CC[C@H](CNc3ccnc(NC[C@H]4CCCO4)n3)CC1)C(C)(C)CCC2(C)C |wU:20.22,wD:30.31,17.18,(.22,-7.48,;-1.11,-6.77,;-2.46,-7.48,;-3.82,-6.77,;-3.82,-5.34,;-2.48,-4.64,;-1.13,-5.34,;.22,-4.63,;1.58,-5.34,;1.56,-6.77,;4.25,-6.77,;4.25,-5.34,;2.91,-4.62,;5.6,-4.64,;5.62,-3.22,;6.95,-5.36,;8.42,-4.48,;9.92,-5.31,;9.92,-7.02,;11.42,-7.84,;12.89,-6.97,;14.38,-7.8,;15.85,-6.94,;17.33,-6.07,;17.3,-4.38,;18.78,-3.5,;20.27,-4.35,;20.28,-6.06,;21.76,-6.9,;23.23,-6.04,;24.73,-6.89,;24.73,-8.6,;27.69,-8.58,;27.68,-6.87,;26.18,-6.02,;18.81,-6.92,;12.87,-5.26,;11.37,-4.41,;-5.14,-4.64,;-6.52,-3.92,;-3.82,-3.92,;-6.49,-5.34,;-6.49,-6.77,;-5.14,-7.47,;-6.52,-8.16,;-3.82,-8.19,)| Show InChI InChI=1S/C38H53N5O3/c1-25-19-31-32(38(4,5)16-15-37(31,2)3)21-28(25)20-29-12-13-33(46-29)35(44)41-23-27-10-8-26(9-11-27)22-40-34-14-17-39-36(43-34)42-24-30-7-6-18-45-30/h12-14,17,19,21,26-27,30H,6-11,15-16,18,20,22-24H2,1-5H3,(H,41,44)(H2,39,40,42,43)/t26-,27-,30-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 175 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro binding affinity towards human gonadotropin-releasing hormone receptor |
Bioorg Med Chem Lett 12: 3635-9 (2002)
BindingDB Entry DOI: 10.7270/Q2XK8DXZ |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50121477
(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)Show SMILES Cc1cc2c(cc1Cc1ccc(o1)C(=O)NC[C@H]1CC[C@H](CNc3ccnc(NC[C@H]4CCCO4)n3)CC1)C(C)(C)CCC2(C)C |wU:20.22,wD:30.31,17.18,(.22,-7.48,;-1.11,-6.77,;-2.46,-7.48,;-3.82,-6.77,;-3.82,-5.34,;-2.48,-4.64,;-1.13,-5.34,;.22,-4.63,;1.58,-5.34,;1.56,-6.77,;4.25,-6.77,;4.25,-5.34,;2.91,-4.62,;5.6,-4.64,;5.62,-3.22,;6.95,-5.36,;8.42,-4.48,;9.92,-5.31,;9.92,-7.02,;11.42,-7.84,;12.89,-6.97,;14.38,-7.8,;15.85,-6.94,;17.33,-6.07,;17.3,-4.38,;18.78,-3.5,;20.27,-4.35,;20.28,-6.06,;21.76,-6.9,;23.23,-6.04,;24.73,-6.89,;24.73,-8.6,;27.69,-8.58,;27.68,-6.87,;26.18,-6.02,;18.81,-6.92,;12.87,-5.26,;11.37,-4.41,;-5.14,-4.64,;-6.52,-3.92,;-3.82,-3.92,;-6.49,-5.34,;-6.49,-6.77,;-5.14,-7.47,;-6.52,-8.16,;-3.82,-8.19,)| Show InChI InChI=1S/C38H53N5O3/c1-25-19-31-32(38(4,5)16-15-37(31,2)3)21-28(25)20-29-12-13-33(46-29)35(44)41-23-27-10-8-26(9-11-27)22-40-34-14-17-39-36(43-34)42-24-30-7-6-18-45-30/h12-14,17,19,21,26-27,30H,6-11,15-16,18,20,22-24H2,1-5H3,(H,41,44)(H2,39,40,42,43)/t26-,27-,30-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 235 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro binding affinity towards rat gonadotropin-releasing hormone receptor |
Bioorg Med Chem Lett 12: 3635-9 (2002)
BindingDB Entry DOI: 10.7270/Q2XK8DXZ |
More data for this
Ligand-Target Pair | |
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