BDBM50121657 5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid [4-(propane-1-sulfonyl)-phenyl]-amide::CHEMBL328395

SMILES: CCCS(=O)(=O)c1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1

InChI Key: InChIKey=QBBCJCXKSNFWBV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50121657   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50121657 (5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...) Show SMILES CCCS(=O)(=O)c1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1 Show InChI InChI=1S/C18H18ClNO4S3/c1-3-10-26(21,22)15-7-5-14(6-8-15)20-27(23,24)18-12(2)16-11-13(19)4-9-17(16)25-18/h4-9,11,20H,3,10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Toa Eiyo Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human chymase				Bioorg Med Chem Lett 13: 4085-8 (2003) BindingDB Entry DOI: 10.7270/Q2QN665P
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM50121657 (5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...) Show SMILES CCCS(=O)(=O)c1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1 Show InChI InChI=1S/C18H18ClNO4S3/c1-3-10-26(21,22)15-7-5-14(6-8-15)20-27(23,24)18-12(2)16-11-13(19)4-9-17(16)25-18/h4-9,11,20H,3,10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	909	n/a	n/a	n/a	n/a	n/a	n/a
TOA EIYO Ltd. Curated by ChEMBL					Assay Description Inhibitory concentration against serine protease chymase was determined				Bioorg Med Chem Lett 13: 25-9 (2002) BindingDB Entry DOI: 10.7270/Q28W3CPQ
					More data for this Ligand-Target Pair