BDBM50122352 (2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid::CHEMBL89058
SMILES: C\C(\C=C\CC1(CC1)c1cc2c(cc1C)C(C)(C)CCC2(C)C)=C/C(O)=O
InChI Key: InChIKey=QCNVQJSKAXKQEF-ZFKNLEDPSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50122352 ((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-9-cis-RA binding to human Retinoid X receptor RXR alpha | Bioorg Med Chem Lett 13: 261-4 (2002) BindingDB Entry DOI: 10.7270/Q29P310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor beta (Mus musculus) | BDBM50122352 ((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR beta | Bioorg Med Chem Lett 13: 261-4 (2002) BindingDB Entry DOI: 10.7270/Q29P310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM50122352 ((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-ATRA binding to human Retinoic acid receptor RAR alpha | Bioorg Med Chem Lett 13: 261-4 (2002) BindingDB Entry DOI: 10.7270/Q29P310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma (Mus musculus) | BDBM50122352 ((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 36 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Transcriptional activation in CV-1 cells expresing mouse Retinoid X receptor RXR gamma | Bioorg Med Chem Lett 13: 261-4 (2002) BindingDB Entry DOI: 10.7270/Q29P310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor beta (Mus musculus) | BDBM50122352 ((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Transcriptional activation in CV-1 cells expresing human Retinoic acid receptor RAR beta | Bioorg Med Chem Lett 13: 261-4 (2002) BindingDB Entry DOI: 10.7270/Q29P310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50122352 ((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Agonistic activity against Retinoic acid receptor RAR beta in CV-1 cells | Bioorg Med Chem Lett 13: 261-4 (2002) BindingDB Entry DOI: 10.7270/Q29P310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50122352 ((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-ATRA binding to human Retinoic acid receptor RAR gamma | Bioorg Med Chem Lett 13: 261-4 (2002) BindingDB Entry DOI: 10.7270/Q29P310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50122352 ((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-ATRA binding to human Retinoic acid receptor RAR gamma | Bioorg Med Chem Lett 13: 261-4 (2002) BindingDB Entry DOI: 10.7270/Q29P310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM50122352 ((2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 153 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-9-cis-RA binding to human Retinoid X receptor RXR gamma | Bioorg Med Chem Lett 13: 261-4 (2002) BindingDB Entry DOI: 10.7270/Q29P310V | |||||||||||
More data for this Ligand-Target Pair |