BindingDB PrimarySearch

BDBM50122770 6-Amino-5-bromo-1H-pyrimidine-2,4-dione::6-Amino-5-bromo-1H-pyrimidine-2,4-dione(6A5BU)::6-amino-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione::6-amino-5-bromopyrimidine-2,4(1H,3H)-dione::6-amino-5-bromouracil::CHEMBL64909

SMILES: Nc1[nH]c(=O)[nH]c(=O)c1Br

InChI Key: InChIKey=FSLBEEVCUZFKRL-UHFFFAOYSA-N

Data: 2 KI 10 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50122770
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory activity against Escherichia coli thymidine phosphorylase				J Med Chem 48: 392-402 (2005) Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory activity against Escherichia coli thymidine phosphorylase				Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Manchester Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase				Eur J Med Chem 43: 1248-60 (2008) Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP
The University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory activity against human thymidine phosphorylase				Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory concentration against thymidine phosphorylase of Escherichia coli				J Med Chem 48: 392-402 (2005) Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Pampa Curated by ChEMBL					Assay Description Inhibition of thymidine phosphorylase (unknown origin)				J Med Chem 62: 1231-1245 (2019) Article DOI: 10.1021/acs.jmedchem.8b01305
Universidade Federal do Pampa Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory concentration against horse liver thymidine phosphorylase of horse liver				J Med Chem 48: 392-402 (2005) Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory concentration against human thymidine phosphorylase				J Med Chem 48: 392-402 (2005) Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of thymidine phosphorylase (unknown origin)				Eur J Med Chem 70: 400-10 (2013) Article DOI: 10.1016/j.ejmech.2013.10.022 BindingDB Entry DOI: 10.7270/Q2CZ38NN
National University of Singapore Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of Thymidine phosphorylase from Escherichia coli				Bioorg Med Chem Lett 14: 5247-50 (2004) Article DOI: 10.1016/j.bmcl.2004.08.036 BindingDB Entry DOI: 10.7270/Q2PR7VGP
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase				J Med Chem 46: 207-9 (2003) Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory concentration against human thymidine phosphorylase				J Med Chem 48: 392-402 (2005) Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair