null

SMILES: Fc1ccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2ccccc2Cl)c(Cl)c1

InChI Key: InChIKey=WFDFOPHPWGDOIZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50122923   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 11/12/13/14 (Homo sapiens (Human))	BDBM50122923 (6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Fc1ccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2ccccc2Cl)c(Cl)c1 Show InChI InChI=1S/C23H13Cl2FN4O/c24-16-5-1-2-6-19(16)30-21(31)11-10-18(28-30)23-22(15-9-8-14(26)13-17(15)25)27-20-7-3-4-12-29(20)23/h1-13H	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	161	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Tumor necrosis factor alpha release from LPS-induced THP-1 cells by ELISA				J Med Chem 46: 349-52 (2003) Article DOI: 10.1021/jm025585h BindingDB Entry DOI: 10.7270/Q27P8XRR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Mus musculus (mouse))	BDBM50122923 (6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Fc1ccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2ccccc2Cl)c(Cl)c1 Show InChI InChI=1S/C23H13Cl2FN4O/c24-16-5-1-2-6-19(16)30-21(31)11-10-18(28-30)23-22(15-9-8-14(26)13-17(15)25)27-20-7-3-4-12-29(20)23/h1-13H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...				J Med Chem 46: 349-52 (2003) Article DOI: 10.1021/jm025585h BindingDB Entry DOI: 10.7270/Q27P8XRR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Mus musculus (mouse))	BDBM50122923 (6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Fc1ccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2ccccc2Cl)c(Cl)c1 Show InChI InChI=1S/C23H13Cl2FN4O/c24-16-5-1-2-6-19(16)30-21(31)11-10-18(28-30)23-22(15-9-8-14(26)13-17(15)25)27-20-7-3-4-12-29(20)23/h1-13H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	171	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003) Article DOI: 10.1021/jm025585h BindingDB Entry DOI: 10.7270/Q27P8XRR
					More data for this Ligand-Target Pair