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SMILES: CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(o1)C(=O)N1Cc2c(nc3ccccc3c2O)C1c1ccc2OCCc2c1

InChI Key: InChIKey=ABOHIXOOXRYIFZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50122986   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50122986
PNG
(3-(2,3-Dihydro-benzofuran-5-yl)-2-{5-[4-(4-methyl-...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(o1)C(=O)N1Cc2c(nc3ccccc3c2O)C1c1ccc2OCCc2c1
Show InChI InChI=1S/C36H32N4O5/c1-38-15-17-39(18-16-38)35(42)23-8-6-22(7-9-23)30-12-13-31(45-30)36(43)40-21-27-32(37-28-5-3-2-4-26(28)34(27)41)33(40)25-10-11-29-24(20-25)14-19-44-29/h2-13,20,33H,14-19,21H2,1H3,(H,37,41)
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Article
PubMed
 1.80n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development L.L.C.

Curated by ChEMBL


Assay Description
Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluated

J Med Chem 46: 441-4 (2003)


Article DOI: 10.1021/jm0202573
BindingDB Entry DOI: 10.7270/Q2QR4WHQ
More data for this
Ligand-Target Pair