BindingDB PrimarySearch

BDBM50123470 (3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methanone::(3-benzylphenyl)(8-hydroxyquinolin-7-yl)methanone::7-(3-benzylbenzoyl)quinolin-8-ol (Compound 7)::CHEMBL35842

SMILES: Oc1c(ccc2cccnc12)C(=O)c1cccc(Cc2ccccc2)c1

InChI Key: InChIKey=HISIYDZZYZHWFN-UHFFFAOYSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50123470
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
HIV-1 Integrase (Human immunodeficiency virus type 1)	BDBM50123470 ((3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methan...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacy, Nirma University, Ahmedabad, 382 481, India.					Assay Description HIV-1 integrase inhibitory activity of compounds were determined using strand transferase inhibitory assay.				Chem Biol Drug Des 83: 154-66 (2014) Article DOI: 10.1111/cbdd.12207 BindingDB Entry DOI: 10.7270/Q2QR4VSW
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50123470 ((3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methan...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integrase				J Med Chem 46: 453-6 (2003) Article DOI: 10.1021/jm025553u BindingDB Entry DOI: 10.7270/Q24T6HRG
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50123470 ((3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methan...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Cyprus Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase strand transfer activity				Bioorg Med Chem 17: 4806-18 (2009) Article DOI: 10.1016/j.bmc.2009.04.058 BindingDB Entry DOI: 10.7270/Q2R49TKS
University of Cyprus Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50123470 ((3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methan...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Inhibitory activity against HIV-1 integrase				Bioorg Med Chem Lett 14: 1447-54 (2004) Article DOI: 10.1016/j.bmcl.2004.01.027 BindingDB Entry DOI: 10.7270/Q2B858PN
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50123470 ((3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methan...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Università di Messina Curated by ChEMBL					Assay Description Strand transfer inhibitory activity against HIV-1 integrase				J Med Chem 48: 7084-8 (2005) Article DOI: 10.1021/jm050549e BindingDB Entry DOI: 10.7270/Q27W6BR1
Università di Messina Curated by ChEMBL					More data for this Ligand-Target Pair