BDBM50123973 3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-hydroxy-acrylamide::CHEMBL148769::US8796330, 147

SMILES: COc1ccc(NC(=O)Nc2ccc(\C=C\C(=O)NO)cc2)cc1OC

InChI Key: InChIKey=YYJQTOKVRNZEPY-BJMVGYQFSA-N

Data: 3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50123973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50123973 (3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-h...) Show SMILES COc1ccc(NC(=O)Nc2ccc(\C=C\C(=O)NO)cc2)cc1OC Show InChI InChI=1S/C18H19N3O5/c1-25-15-9-8-14(11-16(15)26-2)20-18(23)19-13-6-3-12(4-7-13)5-10-17(22)21-24/h3-11,24H,1-2H3,(H,21,22)(H2,19,20,23)/b10-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	37
Methylgene Inc. US Patent					Assay Description For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...				US Patent US8796330 (2014) BindingDB Entry DOI: 10.7270/Q22B8WQW
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50123973 (3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-h...) Show SMILES COc1ccc(NC(=O)Nc2ccc(\C=C\C(=O)NO)cc2)cc1OC Show InChI InChI=1S/C18H19N3O5/c1-25-15-9-8-14(11-16(15)26-2)20-18(23)19-13-6-3-12(4-7-13)5-10-17(22)21-24/h3-11,24H,1-2H3,(H,21,22)(H2,19,20,23)/b10-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aton Pharma, Inc Curated by ChEMBL					Assay Description Inhibitory concentration against human Histone deacetylase 1				J Med Chem 46: 5097-116 (2003) Article DOI: 10.1021/jm0303094 BindingDB Entry DOI: 10.7270/Q2MP5413
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Homo sapiens (Human))	BDBM50123973 (3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-h...) Show SMILES COc1ccc(NC(=O)Nc2ccc(\C=C\C(=O)NO)cc2)cc1OC Show InChI InChI=1S/C18H19N3O5/c1-25-15-9-8-14(11-16(15)26-2)20-18(23)19-13-6-3-12(4-7-13)5-10-17(22)21-24/h3-11,24H,1-2H3,(H,21,22)(H2,19,20,23)/b10-5+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a
Aton Pharma, Inc Curated by ChEMBL					Assay Description Inhibition of acetylation of histone-4 in human T-24 cancer cells				J Med Chem 46: 5097-116 (2003) Article DOI: 10.1021/jm0303094 BindingDB Entry DOI: 10.7270/Q2MP5413
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50123973 (3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-h...) Show SMILES COc1ccc(NC(=O)Nc2ccc(\C=C\C(=O)NO)cc2)cc1OC Show InChI InChI=1S/C18H19N3O5/c1-25-15-9-8-14(11-16(15)26-2)20-18(23)19-13-6-3-12(4-7-13)5-10-17(22)21-24/h3-11,24H,1-2H3,(H,21,22)(H2,19,20,23)/b10-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1)				J Med Chem 46: 820-30 (2003) Article DOI: 10.1021/jm020377a BindingDB Entry DOI: 10.7270/Q22V2FG8
					More data for this Ligand-Target Pair