BDBM50125260 2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-ethyl}-2,3,4,5-tetrahydro-benzo[c]azepin-1-one::CHEMBL273921
SMILES: Fc1ccc2n(C3CCN(CCN4CCCc5ccccc5C4=O)CC3)c(=O)[nH]c2c1
InChI Key: InChIKey=KOTITFQGTVUMBT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity at human cloned 5-hydroxytryptamine 7 receptor. | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 2.24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor | J Med Chem 47: 3927-30 (2004) Article DOI: 10.1021/jm0498102 BindingDB Entry DOI: 10.7270/Q2FQ9W2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 234 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human dopamine D2 receptor was determined | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 234 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of [3H]-Raclopride binding to Dopamine receptor D2A in rat | J Med Chem 47: 3927-30 (2004) Article DOI: 10.1021/jm0498102 BindingDB Entry DOI: 10.7270/Q2FQ9W2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 302 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity at human cloned 5-hydroxytryptamine 2A receptor. | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 479 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of [3H]-8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor | J Med Chem 47: 3927-30 (2004) Article DOI: 10.1021/jm0498102 BindingDB Entry DOI: 10.7270/Q2FQ9W2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 479 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor in human using [3H]8-OH-DPAT as radioligand | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determined | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human dopamine D4 receptor was determined | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-HT5A receptor was determined | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human dopamine D3 receptor was determined | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 3.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 2C receptor was determined | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | <3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1B receptor was determined | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | <5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 6 receptor | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1E receptor was determined | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1F receptor was determined | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 1A (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human Cytochrome P450 1A2 | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C19 (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human Cytochrome P450 2C19 | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human cytochrome P450 isoform 2C9 | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human Cytochrome P450 2D6 | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50125260 (2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human Cytochrome P450 3A4 | Bioorg Med Chem Lett 13: 1055-8 (2003) BindingDB Entry DOI: 10.7270/Q2X066D4 | |||||||||||
More data for this Ligand-Target Pair |