BDBM50125349 5-Chloro-3-[2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-4-ylmethyl]-2-propyl-3H-imidazole-4-carboxylic acid methyl ester::CHEMBL12172

SMILES: CCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C

InChI Key: InChIKey=XLCKUSNCRBAKDZ-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50125349   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiotensin II receptor (AT-1) type-1 (RAT)	BDBM50125349 (5-Chloro-3-[2'-(3,4-dimethyl-isoxazol-5-ylsulfamoy...) Show SMILES CCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C Show InChI InChI=1S/C26H27ClN4O5S/c1-5-8-22-28-24(27)23(26(32)35-4)31(22)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)37(33,34)30-25-16(2)17(3)29-36-25/h6-7,9-14,30H,5,8,15H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity towards Angiotensin II receptor, type 1 in rat aortic smooth muscle cells using 0.2 nM [125I]-labeled Sar-Ile-angiotensin II				Bioorg Med Chem Lett 13: 1093-6 (2003) BindingDB Entry DOI: 10.7270/Q2NG4PZP
					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50125349 (5-Chloro-3-[2'-(3,4-dimethyl-isoxazol-5-ylsulfamoy...) Show SMILES CCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C Show InChI InChI=1S/C26H27ClN4O5S/c1-5-8-22-28-24(27)23(26(32)35-4)31(22)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)37(33,34)30-25-16(2)17(3)29-36-25/h6-7,9-14,30H,5,8,15H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	460	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1				Bioorg Med Chem Lett 13: 1093-6 (2003) BindingDB Entry DOI: 10.7270/Q2NG4PZP
					More data for this Ligand-Target Pair