BDBM50125832 (Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester::2-Hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester::CHEMBL16633::CHEMBL177429::CHEMBL456227

SMILES: COC(=O)C(=O)CC(=O)c1ccccc1

InChI Key: InChIKey=AQYAHPDSJAFBOS-UHFFFAOYSA-N

Data: 5 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50125832   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50125832 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid meth...) Show SMILES COC(=O)C(=O)CC(=O)c1ccccc1 Show InChI InChI=1S/C11H10O4/c1-15-11(14)10(13)7-9(12)8-5-3-2-4-6-8/h2-6H,7H2,1H3	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B				J Med Chem 47: 14-7 (2003) Article DOI: 10.1021/jm0342109 BindingDB Entry DOI: 10.7270/Q2736QB8
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50125832 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid meth...) Show SMILES COC(=O)C(=O)CC(=O)c1ccccc1 Show InChI InChI=1S/C11H10O4/c1-15-11(14)10(13)7-9(12)8-5-3-2-4-6-8/h2-6H,7H2,1H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Università di Sassari Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase strand transfer activity				J Med Chem 49: 4248-60 (2006) Article DOI: 10.1021/jm060193m BindingDB Entry DOI: 10.7270/Q2T15384
					More data for this Ligand-Target Pair
PA/PB1 (Hepatitis C virus)	BDBM50125832 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid meth...) Show SMILES COC(=O)C(=O)CC(=O)c1ccccc1 Show InChI InChI=1S/C11H10O4/c1-15-11(14)10(13)7-9(12)8-5-3-2-4-6-8/h2-6H,7H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of cap 1 ALMV primed Influenza transcriptase				Antimicrob Agents Chemother 38: 2827-37 (1995) BindingDB Entry DOI: 10.7270/Q25H7HBP
					More data for this Ligand-Target Pair
PA/PB1 (Hepatitis C virus)	BDBM50125832 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid meth...) Show SMILES COC(=O)C(=O)CC(=O)c1ccccc1 Show InChI InChI=1S/C11H10O4/c1-15-11(14)10(13)7-9(12)8-5-3-2-4-6-8/h2-6H,7H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Roche Discovery Welwyn Curated by ChEMBL					Assay Description Inhibitory concentration against cap-dependent endonuclease activity of influenza virus RNP				J Med Chem 46: 1153-64 (2003) Article DOI: 10.1021/jm020334u BindingDB Entry DOI: 10.7270/Q22J6B6V
					More data for this Ligand-Target Pair
PA/PB1 (Hepatitis C virus)	BDBM50125832 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid meth...) Show SMILES COC(=O)C(=O)CC(=O)c1ccccc1 Show InChI InChI=1S/C11H10O4/c1-15-11(14)10(13)7-9(12)8-5-3-2-4-6-8/h2-6H,7H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Plaque growth inhibition				ACS Chem Biol 7: 526-34 (2012) Article DOI: 10.1021/cb200439z BindingDB Entry DOI: 10.7270/Q2JQ121G
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50125832 ((Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid meth...) Show SMILES COC(=O)C(=O)CC(=O)c1ccccc1 Show InChI InChI=1S/C11H10O4/c1-15-11(14)10(13)7-9(12)8-5-3-2-4-6-8/h2-6H,7H2,1H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Università di Sassari Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase 3' processing activity				J Med Chem 49: 4248-60 (2006) Article DOI: 10.1021/jm060193m BindingDB Entry DOI: 10.7270/Q2T15384
					More data for this Ligand-Target Pair