BDBM50126033 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-trifluoromethoxy-biphenyl-3-carbonitrile::CHEMBL24123

SMILES: Cn1cncc1C(O)(C#Cc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(cc1)C#N

InChI Key: InChIKey=AQRLDBGCWSEIIY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50126033   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126033 (6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...) Show SMILES Cn1cncc1C(O)(C#Cc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H17F3N4O2/c1-35-18-34-17-26(35)27(36,23-9-6-19(15-32)7-10-23)12-11-21-8-5-20(16-33)13-25(21)22-3-2-4-24(14-22)37-28(29,30)31/h2-10,13-14,17-18,36H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.410	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM				Bioorg Med Chem Lett 13: 1293-6 (2003) BindingDB Entry DOI: 10.7270/Q2DV1J8J
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I (Homo sapiens (Human))	BDBM50126033 (6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...) Show SMILES Cn1cncc1C(O)(C#Cc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H17F3N4O2/c1-35-18-34-17-26(35)27(36,23-9-6-19(15-32)7-10-23)12-11-21-8-5-20(16-33)13-25(21)22-3-2-4-24(14-22)37-28(29,30)31/h2-10,13-14,17-18,36H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras				Bioorg Med Chem Lett 13: 1293-6 (2003) BindingDB Entry DOI: 10.7270/Q2DV1J8J
					More data for this Ligand-Target Pair