BDBM50126118 CHEMBL3627747
SMILES: OC(=O)[C@H](CCCn1cc(nn1)-c1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc12
InChI Key: InChIKey=JGNDLRZJCLANMH-VWLOTQADSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDM2-MDMX (Homo sapiens (Human)) | BDBM50126118 (CHEMBL3627747) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of East Anglia Curated by ChEMBL | Assay Description Inhibition of human MDM2 (17 to 125 residues) assessed as apparent inhibition constant for reduction in MDM2 interaction with FAM-LTFEHYWAQLTS-CONH2 ... | Bioorg Med Chem Lett 25: 4878-80 (2015) BindingDB Entry DOI: 10.7270/Q2MS3VK7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MDM2-MDMX (Homo sapiens (Human)) | BDBM50126118 (CHEMBL3627747) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of East Anglia Curated by ChEMBL | Assay Description Inhibition of human MDM2 (17 to 125 residues) assessed as reduction in MDM2 interaction with FAM-LTFEHYWAQLTS-CONH2 peptide incubated for 30 mins by ... | Bioorg Med Chem Lett 25: 4878-80 (2015) BindingDB Entry DOI: 10.7270/Q2MS3VK7 | |||||||||||
More data for this Ligand-Target Pair |