BDBM50126326 1-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile::CHEMBL30118

SMILES: Cn1cncc1C(N1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N

InChI Key: InChIKey=WQCSBRZKGIGNTL-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50126326   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126326 (1-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(N1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:13| Show InChI InChI=1S/C28H23N5/c1-32-19-31-17-27(32)28(22-11-9-20(15-29)10-12-22)33-14-13-23(16-30)26(18-33)25-8-4-6-21-5-2-3-7-24(21)25/h2-12,17,19,28H,13-14,18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of farnesyltransferase				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus)	BDBM50126326 (1-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(N1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:13| Show InChI InChI=1S/C28H23N5/c1-32-19-31-17-27(32)28(22-11-9-20(15-29)10-12-22)33-14-13-23(16-30)26(18-33)25-8-4-6-21-5-2-3-7-24(21)25/h2-12,17,19,28H,13-14,18H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126326 (1-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(N1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:13| Show InChI InChI=1S/C28H23N5/c1-32-19-31-17-27(32)28(22-11-9-20(15-29)10-12-22)33-14-13-23(16-30)26(18-33)25-8-4-6-21-5-2-3-7-24(21)25/h2-12,17,19,28H,13-14,18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.61E+5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair