BindingDB PrimarySearch

BDBM50126335 6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1-methyl-1H-quinolin-2-one::6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-4,5-dihydro-3H-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1-methyl-1H-quinolin-2-one::6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE::6-[Amino-(4-chloro-phenyl)-(1-methyl-1H-imidazol-2-yl)-methyl]-4-(3-chloro-phenyl)-1-methyl-1H-quinolin-2-one::6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1-methyl-1H-quinolin-2-one::CHEMBL289228::R-11577::R-115777::Tipifarnib

SMILES: Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1

InChI Key: InChIKey=AJMGJMVFNFTVRI-UHFFFAOYSA-N

Data: 11 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50126335
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of Geranylgeranylprotein transferase-I -catalyzed incorporation of [3H]-GGPP into biotin YRASNRSCAIL substrate				Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase				Bioorg Med Chem Lett 13: 1543-7 (2003) BindingDB Entry DOI: 10.7270/Q2M61JNS
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL					Assay Description Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase				Bioorg Med Chem Lett 13: 4361-4 (2003) BindingDB Entry DOI: 10.7270/Q25H7FPB
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL					Assay Description Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferase				Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5
					More data for this Ligand-Target Pair
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Bovine geranylgeranyltransferase (GGT)				Bioorg Med Chem Lett 14: 5367-70 (2004) Article DOI: 10.1016/j.bmcl.2004.08.012 BindingDB Entry DOI: 10.7270/Q2NS0TC9
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Bovine farnesyltransferase (FTase)				Bioorg Med Chem Lett 14: 5367-70 (2004) Article DOI: 10.1016/j.bmcl.2004.08.012 BindingDB Entry DOI: 10.7270/Q2NS0TC9
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of geranylgeranyltransferase.				Bioorg Med Chem Lett 13: 1367-71 (2003) BindingDB Entry DOI: 10.7270/Q20K27ZP
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of bovine Geranylgeranyltransferase				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of human recombinant CYP3A4				J Med Chem 52: 1639-47 (2009) Article DOI: 10.1021/jm801313t BindingDB Entry DOI: 10.7270/Q27081BQ
University of Washington Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus)	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cells				Bioorg Med Chem Lett 14: 5367-70 (2004) Article DOI: 10.1016/j.bmcl.2004.08.012 BindingDB Entry DOI: 10.7270/Q2NS0TC9
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus)	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) Curated by ChEMBL					Assay Description Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptide				Bioorg Med Chem Lett 13: 4365-9 (2003) BindingDB Entry DOI: 10.7270/Q21R6PX5
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of bovine farnesyltransferase				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair