BDBM50126442 CHEMBL285916::N*1*-[7-(3-Chloro-phenyl)-[1,6]naphthyridin-5-yl]-propane-1,3-diamine::N1-(7-(3-chlorophenyl)-1,6-naphthyridin-5-yl)propane-1,3-diamine

SMILES: NCCCNc1nc(cc2ncccc12)-c1cccc(Cl)c1

InChI Key: InChIKey=GOYXCTUAUOUVCG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50126442   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50126442 (CHEMBL285916 | N*1*-[7-(3-Chloro-phenyl)-[1,6]naph...) Show SMILES NCCCNc1nc(cc2ncccc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H17ClN4/c18-13-5-1-4-12(10-13)15-11-16-14(6-2-8-20-16)17(22-15)21-9-3-7-19/h1-2,4-6,8,10-11H,3,7,9,19H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against spleen tyrosine kinase (SYK)				Bioorg Med Chem Lett 13: 1415-8 (2003) BindingDB Entry DOI: 10.7270/Q2MC8ZCJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50126442 (CHEMBL285916 | N*1*-[7-(3-Chloro-phenyl)-[1,6]naph...) Show SMILES NCCCNc1nc(cc2ncccc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H17ClN4/c18-13-5-1-4-12(10-13)15-11-16-14(6-2-8-20-16)17(22-15)21-9-3-7-19/h1-2,4-6,8,10-11H,3,7,9,19H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Rigel, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK				J Med Chem 55: 3614-43 (2012) Article DOI: 10.1021/jm201271b BindingDB Entry DOI: 10.7270/Q2NZ88RC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50126442 (CHEMBL285916 | N*1*-[7-(3-Chloro-phenyl)-[1,6]naph...) Show SMILES NCCCNc1nc(cc2ncccc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H17ClN4/c18-13-5-1-4-12(10-13)15-11-16-14(6-2-8-20-16)17(22-15)21-9-3-7-19/h1-2,4-6,8,10-11H,3,7,9,19H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant Syk (unknown origin)				Bioorg Med Chem Lett 19: 1944-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.049 BindingDB Entry DOI: 10.7270/Q2WM1D98
					More data for this Ligand-Target Pair