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BDBM50126443 CHEMBL30678::N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin-5-yl]-propane-1,3-diamine::N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5-yl)propane-1,3-diamine

SMILES: CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1

InChI Key: InChIKey=RIWJHDIYQSQOAT-UHFFFAOYSA-N

Data: 5 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50126443   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50126443
PNG
(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Show SMILES CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1
Show InChI InChI=1S/C19H23N5/c1-24(2)15-8-6-14(7-9-15)17-13-18-16(5-3-11-21-18)19(23-17)22-12-4-10-20/h3,5-9,11,13H,4,10,12,20H2,1-2H3,(H,22,23)
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n/an/a 34n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against spleen tyrosine kinase (SYK)


Bioorg Med Chem Lett 13: 1415-8 (2003)


BindingDB Entry DOI: 10.7270/Q2MC8ZCJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50126443
PNG
(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Show SMILES CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1
Show InChI InChI=1S/C19H23N5/c1-24(2)15-8-6-14(7-9-15)17-13-18-16(5-3-11-21-18)19(23-17)22-12-4-10-20/h3,5-9,11,13H,4,10,12,20H2,1-2H3,(H,22,23)
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n/an/a 951n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50126443
PNG
(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Show SMILES CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1
Show InChI InChI=1S/C19H23N5/c1-24(2)15-8-6-14(7-9-15)17-13-18-16(5-3-11-21-18)19(23-17)22-12-4-10-20/h3,5-9,11,13H,4,10,12,20H2,1-2H3,(H,22,23)
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n/an/a 34n/an/an/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50126443
PNG
(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Show SMILES CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1
Show InChI InChI=1S/C19H23N5/c1-24(2)15-8-6-14(7-9-15)17-13-18-16(5-3-11-21-18)19(23-17)22-12-4-10-20/h3,5-9,11,13H,4,10,12,20H2,1-2H3,(H,22,23)
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n/an/a 34n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Syk (unknown origin)


Bioorg Med Chem Lett 19: 1944-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.049
BindingDB Entry DOI: 10.7270/Q2WM1D98
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50126443
PNG
(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Show SMILES CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1
Show InChI InChI=1S/C19H23N5/c1-24(2)15-8-6-14(7-9-15)17-13-18-16(5-3-11-21-18)19(23-17)22-12-4-10-20/h3,5-9,11,13H,4,10,12,20H2,1-2H3,(H,22,23)
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n/an/a 552n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)