BDBM50126730 2-(2,6-Dichloro-phenylamino)-6-(2-hydroxy-ethyl)-1,7-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL27079

SMILES: Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1CCO

InChI Key: InChIKey=DCVKALMAVBGUEW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126730   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50126730 (2-(2,6-Dichloro-phenylamino)-6-(2-hydroxy-ethyl)-1...) Show SMILES Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1CCO Show InChI InChI=1S/C20H18Cl2N4O2/c1-10-11(8-9-27)12-6-7-15-18(16(12)19(28)23-10)26(2)20(24-15)25-17-13(21)4-3-5-14(17)22/h3-7,27H,8-9H2,1-2H3,(H,23,28)(H,24,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase				J Med Chem 46: 1337-49 (2003) Article DOI: 10.1021/jm020446l BindingDB Entry DOI: 10.7270/Q2DN44FW
					More data for this Ligand-Target Pair