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BDBM50126733 2-(2,6-Dichloro-phenylamino)-7-hydroxymethyl-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL27302

SMILES: Cc1c(CO)[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc12

InChI Key: InChIKey=DVCWNIIITNXJFM-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126733   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50126733
PNG
(2-(2,6-Dichloro-phenylamino)-7-hydroxymethyl-1,6-d...)
Show SMILES Cc1c(CO)[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc12
Show InChI InChI=1S/C19H16Cl2N4O2/c1-9-10-6-7-13-17(15(10)18(27)22-14(9)8-26)25(2)19(23-13)24-16-11(20)4-3-5-12(16)21/h3-7,26H,8H2,1-2H3,(H,22,27)(H,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 770n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of p56 Lck tyrosine kinase


J Med Chem 46: 1337-49 (2003)


Article DOI: 10.1021/jm020446l
BindingDB Entry DOI: 10.7270/Q2DN44FW
More data for this
Ligand-Target Pair