BDBM50126744 2-(2,6-Dichloro-phenylamino)-4-[(4-methoxy-benzylamino)-methyl]-1,6,7-trimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL280565

SMILES: COc1ccc(CNCc2cc3c(C)c(C)[nH]c(=O)c3c3n(C)c(Nc4c(Cl)cccc4Cl)nc23)cc1

InChI Key: InChIKey=CABKXSSPRMCOHF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126744   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50126744 (2-(2,6-Dichloro-phenylamino)-4-[(4-methoxy-benzyla...) Show SMILES COc1ccc(CNCc2cc3c(C)c(C)[nH]c(=O)c3c3n(C)c(Nc4c(Cl)cccc4Cl)nc23)cc1 Show InChI InChI=1S/C28H27Cl2N5O2/c1-15-16(2)32-27(36)23-20(15)12-18(14-31-13-17-8-10-19(37-4)11-9-17)24-26(23)35(3)28(33-24)34-25-21(29)6-5-7-22(25)30/h5-12,31H,13-14H2,1-4H3,(H,32,36)(H,33,34)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase				J Med Chem 46: 1337-49 (2003) Article DOI: 10.1021/jm020446l BindingDB Entry DOI: 10.7270/Q2DN44FW
					More data for this Ligand-Target Pair