BDBM50126756 2-(2,6-Dichloro-phenylamino)-4-(2,6-difluoro-pyridin-3-yl)-1,6,7-trimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL26625

SMILES: Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3c(cc2c1C)-c1ccc(F)nc1F

InChI Key: InChIKey=IJQMOGYNJJLTLT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126756   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50126756 (2-(2,6-Dichloro-phenylamino)-4-(2,6-difluoro-pyrid...) Show SMILES Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3c(cc2c1C)-c1ccc(F)nc1F Show InChI InChI=1S/C24H17Cl2F2N5O/c1-10-11(2)29-23(34)18-13(10)9-14(12-7-8-17(27)30-22(12)28)19-21(18)33(3)24(31-19)32-20-15(25)5-4-6-16(20)26/h4-9H,1-3H3,(H,29,34)(H,31,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase				J Med Chem 46: 1337-49 (2003) Article DOI: 10.1021/jm020446l BindingDB Entry DOI: 10.7270/Q2DN44FW
					More data for this Ligand-Target Pair