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BDBM50126760 2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-(3-morpholin-4-yl-3-oxo-propyl)-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL26147

SMILES: Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1CCC(=O)N1CCOCC1

InChI Key: InChIKey=ISNFTACXVBSUFU-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126760   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50126760
PNG
(2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-(3-mor...)
Show SMILES Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1CCC(=O)N1CCOCC1
Show InChI InChI=1S/C25H25Cl2N5O3/c1-14-15(7-9-20(33)32-10-12-35-13-11-32)16-6-8-19-23(21(16)24(34)28-14)31(2)25(29-19)30-22-17(26)4-3-5-18(22)27/h3-6,8H,7,9-13H2,1-2H3,(H,28,34)(H,29,30)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of p56 Lck tyrosine kinase


J Med Chem 46: 1337-49 (2003)


Article DOI: 10.1021/jm020446l
BindingDB Entry DOI: 10.7270/Q2DN44FW
More data for this
Ligand-Target Pair