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BDBM50127306 5-[(5-Cyano-3'-trifluoromethoxy-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile::CHEMBL38615

SMILES: Cn1cncc1C(OCc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(nc1)C#N

InChI Key: InChIKey=ZCOVCZOOFBWXSI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50127306   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50127306
PNG
(5-[(5-Cyano-3'-trifluoromethoxy-biphenyl-2-ylmetho...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(nc1)C#N
Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-24(34)25(19-7-8-21(12-31)33-13-19)35-15-20-6-5-17(11-30)9-23(20)18-3-2-4-22(10-18)36-26(27,28)29/h2-10,13-14,16,25H,15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase


Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I


(Homo sapiens (Human))
BDBM50127306
PNG
(5-[(5-Cyano-3'-trifluoromethoxy-biphenyl-2-ylmetho...)
Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(nc1)C#N
Show InChI InChI=1S/C26H18F3N5O2/c1-34-16-32-14-24(34)25(19-7-8-21(12-31)33-13-19)35-15-20-6-5-17(11-30)9-23(20)18-3-2-4-22(10-18)36-26(27,28)29/h2-10,13-14,16,25H,15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 990n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I


Bioorg Med Chem Lett 13: 1571-4 (2003)


BindingDB Entry DOI: 10.7270/Q27080TK
More data for this
Ligand-Target Pair