BDBM50127309 4-{6-Cyano-3-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-pyridin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester::CHEMBL41518

SMILES: Cn1cncc1C(OCc1ccc(nc1N1CCN(CC1)C(=O)OC(C)(C)C)C#N)c1ccc(cc1)C#N

InChI Key: InChIKey=BLLWRZKPPHTMHT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50127309   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50127309 (4-{6-Cyano-3-[(4-cyano-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Cn1cncc1C(OCc1ccc(nc1N1CCN(CC1)C(=O)OC(C)(C)C)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H31N7O3/c1-28(2,3)38-27(36)35-13-11-34(12-14-35)26-22(9-10-23(16-30)32-26)18-37-25(24-17-31-19-33(24)4)21-7-5-20(15-29)6-8-21/h5-10,17,19,25H,11-14,18H2,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I (Homo sapiens (Human))	BDBM50127309 (4-{6-Cyano-3-[(4-cyano-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Cn1cncc1C(OCc1ccc(nc1N1CCN(CC1)C(=O)OC(C)(C)C)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H31N7O3/c1-28(2,3)38-27(36)35-13-11-34(12-14-35)26-22(9-10-23(16-30)32-26)18-37-25(24-17-31-19-33(24)4)21-7-5-20(15-29)6-8-21/h5-10,17,19,25H,11-14,18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair