BDBM50127727 (E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-3-methyl-phenoxy)-benzo[b]thiophen-2-yl]-2-pyridin-4-yl-acrylic acid::CHEMBL296520

SMILES: Cc1cc(Oc2c(\C=C(\C(O)=O)c3ccncc3)sc3cc(OCc4ccc(cc4)-c4ccccc4)c(OCc4ccc(cc4)-c4ccccc4)cc23)ccc1Cl

InChI Key: InChIKey=SJPGUIOCIRIKPR-SISPBFPDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50127727   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen activator inhibitor-1 (Homo sapiens (Human))	BDBM50127727 ((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-...) Show SMILES Cc1cc(Oc2c(\C=C(\C(O)=O)c3ccncc3)sc3cc(OCc4ccc(cc4)-c4ccccc4)c(OCc4ccc(cc4)-c4ccccc4)cc23)ccc1Cl Show InChI InChI=1S/C49H36ClNO5S/c1-32-26-40(20-21-43(32)50)56-48-42-27-44(54-30-33-12-16-37(17-13-33)35-8-4-2-5-9-35)45(55-31-34-14-18-38(19-15-34)36-10-6-3-7-11-36)29-46(42)57-47(48)28-41(49(52)53)39-22-24-51-25-23-39/h2-29H,30-31H2,1H3,(H,52,53)/b41-28+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...				Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB
					More data for this Ligand-Target Pair