BDBM50127739 (E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(3,4-difluoro-phenoxy)-benzo[b]thiophen-2-yl]-2-pyridin-4-yl-acrylic acid::CHEMBL44584

SMILES: OC(=O)C(=C\c1sc2cc(OCc3ccc(cc3)-c3ccccc3)c(OCc3ccc(cc3)-c3ccccc3)cc2c1Oc1ccc(F)c(F)c1)\c1ccncc1

InChI Key: InChIKey=QOONAMFSJFYYLA-XOKHWMEBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50127739   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen activator inhibitor-1 (Homo sapiens (Human))	BDBM50127739 ((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(3,4-diflu...) Show SMILES OC(=O)C(=C\c1sc2cc(OCc3ccc(cc3)-c3ccccc3)c(OCc3ccc(cc3)-c3ccccc3)cc2c1Oc1ccc(F)c(F)c1)\c1ccncc1 Show InChI InChI=1S/C48H33F2NO5S/c49-41-20-19-38(25-42(41)50)56-47-40-26-43(54-29-31-11-15-35(16-12-31)33-7-3-1-4-8-33)44(55-30-32-13-17-36(18-14-32)34-9-5-2-6-10-34)28-45(40)57-46(47)27-39(48(52)53)37-21-23-51-24-22-37/h1-28H,29-30H2,(H,52,53)/b39-27+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...				Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB
					More data for this Ligand-Target Pair