BDBM50127749 (E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-3,5-dimethyl-phenoxy)-benzo[b]thiophen-2-yl]-2-pyridin-4-yl-acrylic acid::CHEMBL295452

SMILES: Cc1cc(Oc2c(\C=C(\C(O)=O)c3ccncc3)sc3cc(OCc4ccc(cc4)-c4ccccc4)c(OCc4ccc(cc4)-c4ccccc4)cc23)cc(C)c1Cl

InChI Key: InChIKey=GCYVKPLJHDDRTP-VSMKPTLZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50127749   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen activator inhibitor-1 (Homo sapiens (Human))	BDBM50127749 ((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-...) Show SMILES Cc1cc(Oc2c(\C=C(\C(O)=O)c3ccncc3)sc3cc(OCc4ccc(cc4)-c4ccccc4)c(OCc4ccc(cc4)-c4ccccc4)cc23)cc(C)c1Cl Show InChI InChI=1S/C50H38ClNO5S/c1-32-25-41(26-33(2)48(32)51)57-49-43-27-44(55-30-34-13-17-38(18-14-34)36-9-5-3-6-10-36)45(56-31-35-15-19-39(20-16-35)37-11-7-4-8-12-37)29-46(43)58-47(49)28-42(50(53)54)40-21-23-52-24-22-40/h3-29H,30-31H2,1-2H3,(H,53,54)/b42-28+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...				Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB
					More data for this Ligand-Target Pair