BindingDB PrimarySearch

BDBM50128281 18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione; methane sulphonic acid salt::CHEMBL432130

SMILES: CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21

InChI Key: InChIKey=ZCBUQCWBWNUWSU-SFHVURJKSA-N

Data: 11 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50128281
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein kinase C, eta (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C eta				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C alpha				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C zeta				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, gamma (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C gamma				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
CaM kinase II (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinase				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C delta				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C epsilon				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of purified rat brain protein kinase C (RB-PKC)				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C beta 1				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50128281 (18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C beta 2				Bioorg Med Chem Lett 13: 1857-9 (2003) BindingDB Entry DOI: 10.7270/Q2319V87
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair