Found 4 hits for monomerid = 50128642 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50128642
(1-(4-(thiophen-2-yl)benzyl)-N-hydroxy-4-(4-methoxy...)Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(cc2)-c2cccs2)CC1)C(=O)NO Show InChI InChI=1S/C24H26N2O5S2/c1-31-20-8-10-21(11-9-20)33(29,30)24(23(27)25-28)12-14-26(15-13-24)17-18-4-6-19(7-5-18)22-3-2-16-32-22/h2-11,16,28H,12-15,17H2,1H3,(H,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 531 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against matrix metalloprotease-1 |
J Med Chem 46: 2376-96 (2003)
Article DOI: 10.1021/jm0205550 BindingDB Entry DOI: 10.7270/Q2N0178C |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50128642
(1-(4-(thiophen-2-yl)benzyl)-N-hydroxy-4-(4-methoxy...)Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(cc2)-c2cccs2)CC1)C(=O)NO Show InChI InChI=1S/C24H26N2O5S2/c1-31-20-8-10-21(11-9-20)33(29,30)24(23(27)25-28)12-14-26(15-13-24)17-18-4-6-19(7-5-18)22-3-2-16-32-22/h2-11,16,28H,12-15,17H2,1H3,(H,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against matrix metalloprotease-9. |
J Med Chem 46: 2376-96 (2003)
Article DOI: 10.1021/jm0205550 BindingDB Entry DOI: 10.7270/Q2N0178C |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50128642
(1-(4-(thiophen-2-yl)benzyl)-N-hydroxy-4-(4-methoxy...)Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(cc2)-c2cccs2)CC1)C(=O)NO Show InChI InChI=1S/C24H26N2O5S2/c1-31-20-8-10-21(11-9-20)33(29,30)24(23(27)25-28)12-14-26(15-13-24)17-18-4-6-19(7-5-18)22-3-2-16-32-22/h2-11,16,28H,12-15,17H2,1H3,(H,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 273 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE). |
J Med Chem 46: 2376-96 (2003)
Article DOI: 10.1021/jm0205550 BindingDB Entry DOI: 10.7270/Q2N0178C |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50128642
(1-(4-(thiophen-2-yl)benzyl)-N-hydroxy-4-(4-methoxy...)Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(cc2)-c2cccs2)CC1)C(=O)NO Show InChI InChI=1S/C24H26N2O5S2/c1-31-20-8-10-21(11-9-20)33(29,30)24(23(27)25-28)12-14-26(15-13-24)17-18-4-6-19(7-5-18)22-3-2-16-32-22/h2-11,16,28H,12-15,17H2,1H3,(H,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against matrix metalloprotease-13. |
J Med Chem 46: 2376-96 (2003)
Article DOI: 10.1021/jm0205550 BindingDB Entry DOI: 10.7270/Q2N0178C |
More data for this Ligand-Target Pair | |