BDBM50129806 CHEMBL3627987
SMILES: [H][C@]1(NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCNC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@H](C)O
InChI Key: InChIKey=IUWLAPVMXODHTM-UWLXSEQGSA-N
Data: 6 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Botulinum neurotoxin type A (Clostridium botulinum) | BDBM50129806 (CHEMBL3627987) | PDB MMDB NCI pathway Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brookhaven National Laboratory Curated by ChEMBL | Assay Description Inhibition of Clostridium botulinum BoNT/A light chain 448 residue preincubated for 30 mins by FRET assay | Bioorg Med Chem 23: 7264-73 (2015) BindingDB Entry DOI: 10.7270/Q2MG7RB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Botulinum neurotoxin type A (Clostridium botulinum) | BDBM50129806 (CHEMBL3627987) | PDB MMDB NCI pathway Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brookhaven National Laboratory Curated by ChEMBL | Assay Description Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 30 mins and TCEP absent during reaction by FRET assay | Bioorg Med Chem 23: 7264-73 (2015) BindingDB Entry DOI: 10.7270/Q2MG7RB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Botulinum neurotoxin type A (Clostridium botulinum) | BDBM50129806 (CHEMBL3627987) | PDB MMDB NCI pathway Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brookhaven National Laboratory Curated by ChEMBL | Assay Description Inhibition of Clostridium botulinum truncated-BoNT/A light chain 424 residue preincubated for 30 mins by FRET assay | Bioorg Med Chem 23: 7264-73 (2015) BindingDB Entry DOI: 10.7270/Q2MG7RB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Botulinum neurotoxin type A (Clostridium botulinum) | BDBM50129806 (CHEMBL3627987) | PDB MMDB NCI pathway Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brookhaven National Laboratory Curated by ChEMBL | Assay Description Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 60 mins and TCEP absent during reaction by FRET assay | Bioorg Med Chem 23: 7264-73 (2015) BindingDB Entry DOI: 10.7270/Q2MG7RB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Botulinum neurotoxin type A (Clostridium botulinum) | BDBM50129806 (CHEMBL3627987) | PDB MMDB NCI pathway Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brookhaven National Laboratory Curated by ChEMBL | Assay Description Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 30 mins and TCEP present during reaction by FRET assay | Bioorg Med Chem 23: 7264-73 (2015) BindingDB Entry DOI: 10.7270/Q2MG7RB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Botulinum neurotoxin type A (Clostridium botulinum) | BDBM50129806 (CHEMBL3627987) | PDB MMDB NCI pathway Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 162 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brookhaven National Laboratory Curated by ChEMBL | Assay Description Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 60 mins and TCEP present during reaction by FRET assay | Bioorg Med Chem 23: 7264-73 (2015) BindingDB Entry DOI: 10.7270/Q2MG7RB8 | |||||||||||
More data for this Ligand-Target Pair |