BDBM50130024 2-(2-Methyl-pyridin-4-ylmethyl)-1-oxo-8-(2-pyridin-2-yl-ethoxy)-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester with 2moles of hydrochloride::CHEMBL539783
SMILES: COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccnc(OCCc3ccccn3)c2c(=O)n1Cc1ccnc(C)c1
InChI Key: InChIKey=IQLHTXVSILCMMJ-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris) | BDBM50130024 (2-(2-Methyl-pyridin-4-ylmethyl)-1-oxo-8-(2-pyridin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lung | Bioorg Med Chem Lett 13: 2341-5 (2003) BindingDB Entry DOI: 10.7270/Q2WQ04B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 2A (Bos taurus) | BDBM50130024 (2-(2-Methyl-pyridin-4-ylmethyl)-1-oxo-8-(2-pyridin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against phosphodiesterase-2 (PDE2) isolated from bovine adrenal gland | Bioorg Med Chem Lett 13: 2341-5 (2003) BindingDB Entry DOI: 10.7270/Q2WQ04B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 4 (Homo sapiens (Human)) | BDBM50130024 (2-(2-Methyl-pyridin-4-ylmethyl)-1-oxo-8-(2-pyridin...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against phosphodiesterase 4 (PDE4) isolated from canine lung | Bioorg Med Chem Lett 13: 2341-5 (2003) BindingDB Entry DOI: 10.7270/Q2WQ04B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 6 (Bos taurus-Bos taurus (Bovine)) | BDBM50130024 (2-(2-Methyl-pyridin-4-ylmethyl)-1-oxo-8-(2-pyridin...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against Phosphodiesterase 6 isolated from bovine retina | Bioorg Med Chem Lett 13: 2341-5 (2003) BindingDB Entry DOI: 10.7270/Q2WQ04B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 1 (Homo sapiens (Human)) | BDBM50130024 (2-(2-Methyl-pyridin-4-ylmethyl)-1-oxo-8-(2-pyridin...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against phosphodiesterase-1 (PDE1) isolated from canine lung | Bioorg Med Chem Lett 13: 2341-5 (2003) BindingDB Entry DOI: 10.7270/Q2WQ04B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50130024 (2-(2-Methyl-pyridin-4-ylmethyl)-1-oxo-8-(2-pyridin...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against phosphodiesterase-3 (PDE3) isolated from canine heart | Bioorg Med Chem Lett 13: 2341-5 (2003) BindingDB Entry DOI: 10.7270/Q2WQ04B2 | |||||||||||
More data for this Ligand-Target Pair |