BDBM50130264 5-(1,4-diazepan-1-yl)-2-(4-fluorophenylsulfonyl)-N-methylbenzenamine::CHEMBL95136::[5-[1,4]Diazepan-1-yl-2-(4-fluoro-benzenesulfonyl)-phenyl]-methyl-amine
SMILES: CNc1cc(ccc1S(=O)(=O)c1ccc(F)cc1)N1CCCNCC1
InChI Key: InChIKey=UEDJZAWDDUJLFY-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50130264 (5-(1,4-diazepan-1-yl)-2-(4-fluorophenylsulfonyl)-N...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 6 receptor | J Med Chem 46: 2795-812 (2003) Article DOI: 10.1021/jm030030n BindingDB Entry DOI: 10.7270/Q2M0465F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50130264 (5-(1,4-diazepan-1-yl)-2-(4-fluorophenylsulfonyl)-N...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology Curated by ChEMBL | Assay Description Displacement of [3H]-LSD from human cloned 5HT6 receptor expressed in HEK293 cells | Bioorg Med Chem Lett 18: 738-43 (2008) Article DOI: 10.1016/j.bmcl.2007.11.045 BindingDB Entry DOI: 10.7270/Q2XK8F99 | |||||||||||
More data for this Ligand-Target Pair |