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BDBM50130611 2-Amino-N-{4-[2-amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionylamino]-butyl}-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionamide::CHEMBL108640

SMILES: Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCNC(=O)[C@H](N)Cc1c(C)cc(O)cc1C

InChI Key: InChIKey=XNDDFGCHFYFKSW-PSWAGMNNSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50130611   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50130611
PNG
(2-Amino-N-{4-[2-amino-3-(4-hydroxy-2,6-dimethyl-ph...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCNC(=O)[C@H](N)Cc1c(C)cc(O)cc1C
Show InChI InChI=1S/C26H38N4O4/c1-15-9-19(31)10-16(2)21(15)13-23(27)25(33)29-7-5-6-8-30-26(34)24(28)14-22-17(3)11-20(32)12-18(22)4/h9-12,23-24,31-32H,5-8,13-14,27-28H2,1-4H3,(H,29,33)(H,30,34)/t23-,24+
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
0.0400n/an/an/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor mu 1 using [3H]-DAGO in rat brain P2 synaptosomal preparation


J Med Chem 46: 3201-9 (2003)


Article DOI: 10.1021/jm020459z
BindingDB Entry DOI: 10.7270/Q28C9VMQ
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50130611
PNG
(2-Amino-N-{4-[2-amino-3-(4-hydroxy-2,6-dimethyl-ph...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCNC(=O)[C@H](N)Cc1c(C)cc(O)cc1C
Show InChI InChI=1S/C26H38N4O4/c1-15-9-19(31)10-16(2)21(15)13-23(27)25(33)29-7-5-6-8-30-26(34)24(28)14-22-17(3)11-20(32)12-18(22)4/h9-12,23-24,31-32H,5-8,13-14,27-28H2,1-4H3,(H,29,33)(H,30,34)/t23-,24+
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53n/an/an/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Binding affinity for Opioid receptor delta 1 using [3H]-DPDPE in rat brain P2 synaptosomal preparation


J Med Chem 46: 3201-9 (2003)


Article DOI: 10.1021/jm020459z
BindingDB Entry DOI: 10.7270/Q28C9VMQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)
BDBM50130611
PNG
(2-Amino-N-{4-[2-amino-3-(4-hydroxy-2,6-dimethyl-ph...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCNC(=O)[C@H](N)Cc1c(C)cc(O)cc1C
Show InChI InChI=1S/C26H38N4O4/c1-15-9-19(31)10-16(2)21(15)13-23(27)25(33)29-7-5-6-8-30-26(34)24(28)14-22-17(3)11-20(32)12-18(22)4/h9-12,23-24,31-32H,5-8,13-14,27-28H2,1-4H3,(H,29,33)(H,30,34)/t23-,24+
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n/an/a 5.30n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Opioid receptor mu 1 agonism in guinea pig ileum


J Med Chem 46: 3201-9 (2003)


Article DOI: 10.1021/jm020459z
BindingDB Entry DOI: 10.7270/Q28C9VMQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)
BDBM50130611
PNG
(2-Amino-N-{4-[2-amino-3-(4-hydroxy-2,6-dimethyl-ph...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCNC(=O)[C@H](N)Cc1c(C)cc(O)cc1C
Show InChI InChI=1S/C26H38N4O4/c1-15-9-19(31)10-16(2)21(15)13-23(27)25(33)29-7-5-6-8-30-26(34)24(28)14-22-17(3)11-20(32)12-18(22)4/h9-12,23-24,31-32H,5-8,13-14,27-28H2,1-4H3,(H,29,33)(H,30,34)/t23-,24+
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 agonism in mouse vas deferens


J Med Chem 46: 3201-9 (2003)


Article DOI: 10.1021/jm020459z
BindingDB Entry DOI: 10.7270/Q28C9VMQ
More data for this
Ligand-Target Pair