BindingDB PrimarySearch

null

SMILES: Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12

InChI Key: InChIKey=UQPMANVRZYYQMD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50130693
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of MNK1 (unknown origin) using S3 as substrate measured after 60 mins by HTRF assay				Bioorg Med Chem 26: 4602-4614 (2018) Article DOI: 10.1016/j.bmc.2018.05.004 BindingDB Entry DOI: 10.7270/Q2CF9SR9
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...				Eur J Med Chem 163: 413-427 (2019) Article DOI: 10.1016/j.ejmech.2018.11.072 BindingDB Entry DOI: 10.7270/Q2736V7K
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00368 BindingDB Entry DOI: 10.7270/Q20C50T2
TBA					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MKN1 (unknown origin) in presence of ATP by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01084 BindingDB Entry DOI: 10.7270/Q2CV4NJ6
TBA					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
University of South Australia Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.113420 BindingDB Entry DOI: 10.7270/Q20Z777Z
TBA					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01941 BindingDB Entry DOI: 10.7270/Q200065B
TBA					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of MNK2 (unknown origin) using S3 as substrate measured after 60 mins by HTRF assay				Bioorg Med Chem 26: 4602-4614 (2018) Article DOI: 10.1016/j.bmc.2018.05.004 BindingDB Entry DOI: 10.7270/Q2CF9SR9
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of MNK2 (unknown origin)				Bioorg Med Chem 26: 4602-4614 (2018) Article DOI: 10.1016/j.bmc.2018.05.004 BindingDB Entry DOI: 10.7270/Q2CF9SR9
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 45 mins by ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
University of South Australia Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of MNK2 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...				Eur J Med Chem 163: 413-427 (2019) Article DOI: 10.1016/j.ejmech.2018.11.072 BindingDB Entry DOI: 10.7270/Q2736V7K
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.113420 BindingDB Entry DOI: 10.7270/Q20Z777Z
TBA					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00368 BindingDB Entry DOI: 10.7270/Q20C50T2
TBA					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MKN2 (unknown origin) in presence of ATP by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01084 BindingDB Entry DOI: 10.7270/Q2CV4NJ6
TBA					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.113420 BindingDB Entry DOI: 10.7270/Q20Z777Z
TBA					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chengdu Medical College Curated by ChEMBL					Assay Description Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assay				Bioorg Med Chem 27: 2268-2279 (2019) Article DOI: 10.1016/j.bmc.2019.04.022 BindingDB Entry DOI: 10.7270/Q24F1V2Z
Chengdu Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.113420 BindingDB Entry DOI: 10.7270/Q20Z777Z
TBA					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01941 BindingDB Entry DOI: 10.7270/Q200065B
TBA					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of CDK9/cyclinT1 (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measure...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
University of South Australia Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
University of South Australia Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of CDK2/cyclinA (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
University of South Australia Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130693 (CGP-57380 \| CHEMBL1240885) Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
University of South Australia Curated by ChEMBL					More data for this Ligand-Target Pair