BDBM50131134 2-(6-Methyl-2-morpholin-4-ylmethyl-pyrimidin-4-ylamino)-benzothiazole-6-carboxylic acid (2-chloro-6-methyl-phenyl)-amide::CHEMBL423312

SMILES: Cc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(CN2CCOCC2)n1

InChI Key: InChIKey=CSVBNLZQQMJJTJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50131134   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50131134 (2-(6-Methyl-2-morpholin-4-ylmethyl-pyrimidin-4-yla...) Show SMILES Cc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(CN2CCOCC2)n1 Show InChI InChI=1S/C25H25ClN6O2S/c1-15-4-3-5-18(26)23(15)31-24(33)17-6-7-19-20(13-17)35-25(28-19)30-21-12-16(2)27-22(29-21)14-32-8-10-34-11-9-32/h3-7,12-13H,8-11,14H2,1-2H3,(H,31,33)(H,27,28,29,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human p56 Lck tyrosine kinase				Bioorg Med Chem Lett 13: 2587-90 (2003) BindingDB Entry DOI: 10.7270/Q2FX78V4
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